Onpattro® (patisiran)
for Transthyretin Amyloid Cardiomyopathy
Onpattro (patisiran) is an injectable small interfering RNA used to treat polyneuropathy caused by hereditary transthyretin-mediated amyloidosis (ATTR) in adults. ATTR occurs when faulty transthyretin (TTR) proteins accumulate in organs and tissues, particularly peripheral nerves. Onpattro works by breaking down both mutant and wild-type TTR proteins through RNA interference, reducing TTR levels and deposits, thereby relieving polyneuropathy symptoms.
