eculizumab
for Paroxysmal Nocturnal Hemoglobinuria

Eculizumab is used to treat paroxysmal nocturnal hemoglobinuria (PNH) in adults, atypical hemolytic uremic syndrome (aHUS) in adults and children weighing at least 11 pounds, generalized myasthenia gravis (gMG) in adults with anti-acetylcholine receptor antibodies, and neuromyelitis optica spectrum disorder (NMOSD) in adults. It works by binding to complement protein C5, preventing its breakdown and protecting red blood cells from destruction.

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