Gavreto (pralsetinib) is an oral targeted therapy used to treat cancers driven by abnormal RET genes, including metastatic non-small cell lung cancer (NSCLC) in adults and advanced thyroid cancer in adults and children 12 and older who need systemic therapy after radioactive iodine has failed. Gavreto blocks the RET protein, which plays a key role in cancer growth, making it effective against RET mutations or fusions.