Savella (milnacipran HCl) is a serotonin-norepinephrine reuptake inhibitor (SNRI) used to manage fibromyalgia. It works by increasing levels of norepinephrine and serotonin in the brain, neurotransmitters believed to play a role in pain regulation. By balancing these chemicals, Savella may help reduce chronic muscle and joint pain associated with fibromyalgia.