Yeztugo® (lenacapavir)
for Human Immunodeficiency Virus

Yeztugo (lenacapavir) is a capsid inhibitor used for pre-exposure prophylaxis (PrEP) to reduce the risk of sexually acquired HIV-1 in adults and adolescents weighing at least 35 kg (77 lbs). It binds to HIV-1 capsid protein subunits, disrupting multiple stages of the viral lifecycle. Yeztugo blocks nuclear import of proviral DNA, interferes with virus assembly and release by reducing capsid production, and prevents proper capsid core formation through malformed assembly.

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